Feeling No Pain: New Form of Rare Gene Disorder Decoded. End of the Story

This phenomenon was described by National Geographic.The story beginning is here. And now -

Learning by Example

Early childhood can be treacherous for people with complete insensitivity to pain.

They can gnaw endlessly on their tongues and fingers during teething, stick their fingers in their eyes, or suffer major injuries without noticing.

The six people studied for the Nature paper all had permanent injuries to their lips or tongues from biting themselves when they were young.
The boy who clued researchers to their presence in Pakistan died after jumping off a house before his fourteenth birthday.

But eventually sufferers can learn what to avoid doing even without pain as a guide.

Paola Sandroni, a neurologist at the Mayo Clinic in Rochester, Minnesota, who was not a member of the research team, had a patient with a nearly identical disorder to the Pakistani subjects.

This patient was very unusual, because he was 20 years old before he was diagnosed with a nerve disorder.

When he was a toddler he complained to his mother that some kids had roughed him up and hurt his feelings. What he didn't mention was that he also had broken his arm.

But eventually, Sandroni said, "he learned by using his intellect and experience of watching others."

He once shocked himself while working on some wiring, for example.

"His arm started jumping, and he felt nothing," Sandroni related.

"He thought it was pretty funny, actually … Then he said, Oh, maybe I shouldn't be touching these wires. So he pulled his hand away and noticed that he had a burn."

When Sandroni reported the diagnosis earlier this year, she couldn't find reports of any other patients with the set of symptoms.

But, she says, the new cases in Pakistan sound very similar.

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